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Biology of the chemokine RANTES

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Published by Springer-Verlag, R.G. Landes in New York, Austin .
Written in English


  • Chemokines.,
  • T cells.,
  • Lymphocyte transformation.,
  • Lymphokines -- immunology.,
  • T-Lymphocytes -- immunology.

Book details:

Edition Notes

Includes bibliographical references and index.

Statement[edited by] Alan M. Krensky.
SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
ContributionsKrensky, Alan M.
LC ClassificationsQR185.8.C45 B56 1995
The Physical Object
Pagination123 p. :
Number of Pages123
ID Numbers
Open LibraryOL1275699M
ISBN 101570592535, 3540592202
LC Control Number95007283

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The proceedings of that meeting were published in Advances in Experimental Medicine and Biology, vol. (). The rapid advances made in the field of chemotactic cytokines over the last 18 months necessitated a third Symposium in this series to collate and place in . Hypertension was associated with an increase in perivascular adipose tissue expression of the chemokine RANTES (relative quantification, ± vs. ± ; Pchemokine Cited by: Summary Interactions of the chemokine CCL5 (RANTES) with glycosaminoglycans (GAGs) are crucial to the CCL5-mediated inflammation process. However, structural information on interactions between CCL5 and longer GAG fragments is by: Both the CC chemokine ligand 5 (CCL5/RANTES) and interleukin-6 (IL-6), released by mesenchymal stem cells (MSCs) as well as by neoplastic cells, promote breast cancer cell progression through autocrine and paracrine mechanisms. In order to assess the .

The aim of this study was to investigate the role of human herpesvirus-6 (HHV-6) in autoimmune thyroiditis (AIT) development. We examined the possible involvement of HHV-6 gene expression encoding immunomodulating proteins U12 and U51 in AIT development and their role in the modulation of chemokine signaling. One hundred patients with autoimmune thyroiditis following thyroidectomy . RANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted) is a chemokine secreted by platelets that have been activated predominantly during flow conditions– This chemokine interacts with P-selectin in mediating monocyte/macrophage infiltration into atherosclerotic lesions.   Abstract RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES receptor, CCR5, is a major target of anti-HIV drugs based on blocking viral entry. Joseph Lorenzo MD, in Osteoimmunology (Second Edition), CCR1. Ligands for CCR1 include CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3), CCL13 (MCP-4), CCL14 (HCC-1), CCL15 (LKN-1), and CCL23 (MPIF-1). Inhibition of CCR1 expression with siRNA, or by blocking NFATc1 activation with cyclosporin A, inhibited migration of RAW cells (a model for osteoclast precursors) and .

The discovery of this fourth type of chemokine raises questions about the evolutionary history of CX 3 C and the other chemokines. The CXC, CC, C and CX 3 C chemokine genes map to human chromosomes 4, 17, 1 respectively. There are some exceptions, for instance SDF-1 maps to chromos and this chemokine may in fact represent a. Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemo tactic cyto kines. Cytokine proteins are classified as chemokines according to behavior and structural ro: IPR Subsequent to the structures of CXCL8 and other CXC chemokines, the structure of the CC chemokine, CCL4/MIP‐1β, was solved, 8 followed by CCL5/RANTES 9 and CCL2/MCP‐1 10 shortly thereafter. These CC chemokine structures revealed a distinctly different dimer motif compared with CXC dimers.   Binding of RANTES/CCL5 to GAGs and to GPCRs are crucial for its pro-inflammatory activity [42–44]. Mutating the main GAG-binding domain in RANTES has been shown to switch the [A 44 ANA 47]-RANTES/CCL5 chemokine to a potent anti-inflammatory molecule in murine models of inflammatory diseases. The anti-inflammatory properties of a RANTES/CCL5.